Hot-melt extrusion (HME) ke ts'ebetso e thehiloeng esale e sebelisoa ho tloha mathoasong a lilemo tsa bo-1930, haholo-holo tlhahisong ea polasetiki ...
Ho na le mefuta e 'meli ea li-extruder: li-extruder tse se nang molekane le tse mafahla.Li-screw extruder tse le 'ngoe li sebelisoa haholo bakeng sa ho qhibilihisa le ho tsamaisa li-polymer ho li hlahisa libopeho tse tsoelang pele, athe li-scruder tse peli li sebelisetsoa ho kopanya li-polymer tse nang le lisebelisoa tse eketsehileng (li-pigments, li-filler, li-reinforcers, le li-API), le bakeng sa devolatilization.Ho hlahisoeng ha metsoako ea meriana, e hlokang motsoako oa homo-geneous le ka mokhoa o tsitsitseng oa metsoako e mengata ea tlhahiso, "twin screw extruder" e khethoa hobane ho potoloha ha li-inter-meshing screws ho fana ka motsoako o betere ho hlahisa homogeneous solid e nang le likaroloana tsa API tse qhalakaneng hantle, kapa tharollo e tiileng ea API ka polymer.Sena se ka ntlafatsa sekhahla sa ho qhibiliha le bokhoni ba bioavail ba litlhophiso tsa API tse qhibilihang hantle metsing.API e arolelanoang ka mokhoa o tšoanang e boetse e hlokahala esale pele bakeng sa tlhahiso ea lisebelisoa tse hlahisang lithethefatsi tse nang le intra- and inter-batch reproducibility of drug-release ki-netics.
Ho qhibiliha ho finyelloa ka ho futhumatsa ka har'a moqomo, le bakeng sa li-extruder tse peli, ha lisebelisoa li ntse li kuta pakeng tsa li-screws tse pota-potileng le pakeng tsa li-screw le lebota la barrel ha li ntse li tsamaisoa.Moqomo o boetse o halefile ka li-heaters tse behiloeng holim'a moqomo, kapa o pholile ka metsi.Hangata mocheso oa karolo ea barrel o optimized e le hore viscosity ea ho qhibiliha e fokotsehe ka ho lekaneng ho lumella ho theola moqomo le ho kopanya hantle, ha mocheso o ntse o le tlase ho lekana ho qoba ho senyeha ha mocheso oa thepa.
Li-screws tsa twin screw extruder hangata li fana ka mefuta e fapaneng ea ho kopanya le ho tsamaisa maemo libakeng tse fapaneng ka moqomong.Nakong ea nts'etsopele ea sehlahisoa, li-screws tsa modular tse nang le li-element tse ngata tse kenngoeng holim'a shaft e tloaelehileng, li lumella ho lokisoa le ho ntlafatsa sebopeho sa screw bakeng sa sehlahisoa ka seng.Likarolo tsa screw li ka etsoa ho fokotsa boholo ba likaroloana, ho kopanya le ho tsamaisa mesebetsi.Bolelele ba screw mabapi le bophara ba barrel (karolelano ea L/D) e khethoa ho ntlafatsa tekanyo ea ho kopanya le palo ea libaka tse hlokahalang ho fihlela sehlahisoa sa ho qetela sa char-acteristics.Mohlala oa sekoti se felletseng sa modular.Li-screw tsa tlhahiso ea karolo e le 'ngoe li ka hahuoa ka moralo o ts'oanang le likurufu tsa nts'etsopele, empa ho bonolo ho li hloekisa bakeng sa ho latela melao ea cGMP.
Nako ea poso: Jun-03-2017